All 2025

Cluster headache is often described by patients and clinicians alike as one of the most severe pains the human body can experience. Yet despite its brutality, the disorder remains underrecognized, underfunded, and frequently misdiagnosed. Affecting roughly 0.1% of the population, cluster headache produces explosive attacks of unilateral pain around the eye or temple, accompanied by autonomic symptoms such as tearing, nasal congestion, and profound physical agitation. For many sufferers, the attacks occur with clocklike precision and can continue for weeks or months, leaving patients trapped in cycles of debilitating pain. This article summarizes major scientific advances reported throughout 2025, including